Objective.
@ES To analyze neurological manifestations in hypereosinophilic syndrome.
@ES Background.
@EN According to Chusid et al (1975), the neurologic manifastations in hypereosinophilic syndrome were paralysis, seizure, abnormal EEG finding, and neuropathy. According to Weaver (1988), eosinophil-induced neurotoxicities were characterized by
axonal
neuropathy, cerebral infarction, and dementia.
@ES Method.
@EN we analyzed 29 patients with neurologic manifestations and hypereosinophilia who visited Kyung Hee medical center during Aug 1991-Jul. 1994. White blood cells were differentiated by the Coulter STKS S-;lus machine and confirmed manually, if
hypereosinophilia had been detected, by two clinical ptahologists. Symtpoms, signs, imaging studies, latoratory studies and biopsies were analyzed.
@ES Reseult.
@EN The mean age was 47.2 years and the mean eosinophil count was 2700/cumm. Main symptoms were hemiparesis (31.0%), dysesthesia (20.7%), headache (20.7%), dysarthria (13.8%), paraparesis (10.3%), seizure (6.9%), 14 patients were shown to have
cerebrovascular disease, 5 patients meningoencephalitis, 4 patients peripheral neuropathy, 3 patients myelopathy.
@ES Conclusion.
@EN Cerebrovascular diseases (48.3%) were most comon neurologic disease in hypereosinophic syndrome. Others were meningoencephalitis (17.2%), polyneuropathy (13.8%), myelopathy (10.3%), eosinophilia myalgia syndrome (6.9%), temporal arteritis
(3.4%).
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